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isotypic是什么意思，isotypic翻译
isotypic
The term "isotypic" refers to a type of immune response that involves the production of antibodies with the same idiotype. Idiotype refers to the specific antigenic determinants on the surface of antibodies. Isotypic antibodies are those that have the same idiotype but may have different constant regions, which determine the effector functions of the antibody.
The isotype of an antibody is determined by the genetic makeup of the individual producing the antibody. There are several different isotypes of antibodies, including IgG, IgM, IgA, IgD, and IgE. Each isotype has a different constant region, which allows them to perform different functions in the immune response. For example, IgG antibodies are involved in neutralizing pathogens and activating the complement system, while IgE antibodies are involved in allergic reactions and parasitic infections.
The production of isotypic antibodies is an important aspect of the immune response. When the body is exposed to an antigen for the first time, B cells differentiate into plasma cells that produce antibodies specific to that antigen. These antibodies have the same idiotype, but they may have different isotypes. As the immune response progresses, the production of isotypic antibodies can be used to monitor the immune status of an individual. For example, the levels of IgG antibodies against certain pathogens can be used to determine if a person has been infected with the pathogen in the past or if they have been vaccinated against it.
Isotypic switching is a process by which B cells can change the isotype of the antibodies they produce in response to different types of immune challenges. This process is mediated by T cells, which provide signals that regulate the production of different isotypes of antibodies. Isotypic switching is an important mechanism for ensuring that the immune system can respond effectively to a wide range of pathogens and other challenges.
In summary, isotypic antibodies are those that have the same idiotype but may have different isotypes. The production of isotypic antibodies is an important aspect of the immune response, and isotypic switching is a mechanism by which the immune system can respond effectively to different types of challenges.